Notts County will be without both Myles Weston (hamstring) and Matthew Hamshaw (knee) for the second game running.
Weston's niggle, in particular, is quite a worry when considering that similar problems restricted his involvement last term.
Both players' omission from the squad is once again a huge blow, which was significantly highlighted in the 6-1 drubbing at the hands of Dagenham & Redbridge.
Joining them on the sidelines are Michael Johnson (toe), Adam Tann (knee), Ben Fairclough (thigh) and Jay Smith (groin).
Stephen Hunt looks set to be involved in the squad for the first time since last season's clash at home to tomorrow's visitors.
Gavin Strachan will also expect to take up a spot on the bench for the second game in a row, following his return from a hamstring injury.
Wycombe Wanderers' boss, Peter Jackson is likely to name the same team that claimed a 4-2 win over Port Vale on Saturday.
Midfielder, Tommy Docherty missed the victory with a thigh injury but may be fit enough to be named as a substitute.
Two more returning players could make the trip to Meadow Lane as well, with defender, Leon Johnson recovering from a shoulder problem and Matty Bloomfield who has overcome a serious knee injury.
On-loan Reading striker, Simon Church will not play because of a broken hand picked up in training.
The Chairboys will also be without striker, Scott McGleish because he has extended his loan spell with Northampton Town for an additional month.